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KMID : 1123920110250010115
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 1 p.115 ~ p.121
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Antioxidant Activity of Black Panax ginseng
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Lee Sook-Young
Kim Dong-Hee
Woo Won-Hong
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Abstract
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This study was performed to investigate the antioxidant activity of extracts of black Panax ginseng (BGE) and its crude saponin (BGECS). The antioxidant activities of BGE and BGECS were evaluated for free radical scavenging activity against stable free radical (1,1-diphenyl-2-picrylhydrazyl) DPPH, nitrite, hydrogen peroxide and superoxide. In addition, the antioxidant activity of BGE and BGECS against peroxyl radicals, hydroxyl radicals and peroxynitrites were determined by the total oxy-radical scavenging capacity (TOSC) assay. As a result, BGE and BGECS were found to have a strong inhibitory activity with >90% against the DPPH radical at 1000㎍/㎖ concentrations. Also, BGE and BGECS exhibited strong inhibitory activity with >80% against hydrogen peroxide at lower concentration (125㎍/㎖). Moreover, specific TOSC values (405 and 473 TOSC/mM) of BGE and BGECS against peroxynitrites were higher than GSH (347 TOSC/mM) used a positive control. These results suggest that BGE and BGECS could be useful to develop functional foods against disease related oxidative stress.
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KEYWORD
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Black Panax ginseng, Antioxidant activity, DPPH, TOSC assay
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